Qing (Robert) Miao, PhD

Associate Professor

Introduction

Qing (Robert) Miao, PhD

Qing (Robert) Miao, PhD

Qing Robert Miao, PhD is internationally recognized for his research on elucidating the biological functions of Nogo-B receptor and its roles in the pathogenesis of human diseases. Nogo-B receptor (NgBR) is a new cell surface receptor that was identified by Dr. Miao during his postdoctoral training in Dr. William Sessa’s laboratory at the Yale School of Medicine. His continuous work at the MCW demonstrated that NgBR is a vital gene required for the development and loss of NgBR causes the early embryonic lethality.

Dr. Miao’s significant contribution to science is elucidating the unique properties of NgBR binding prenylated Ras and regulates Ras plasma membrane translocation, which is an important cell process required for many receptor tyrosine kinase-mediated pathways. This innovative discovery not only reveals why NgBR is an essential gene for development but also opens a new research avenue in developing a new therapeutic approach targeting the concurrent receptor tyrosine kinase-mediated tumorigenic pathways.

Dr. Miao’s innovative research program successfully connects their bench work with human diseases and strengthens the translational aspect of their research through the collaboration with clinical colleagues at MCW. Based on the determination of physiological defects happened in NgBR tissue-specific transgenic mice, Dr. Miao’s research team successfully established several unique animal models for elucidating the novel underlying mechanisms of human diseases, such as cerebrovascular malformations and nonalcoholic fatty liver diseases. Dr. Miao’s career establishment is evidenced by the continuous success of NIH and AHA funding as well as the Mid-Career Investigator Award from American Heart Association’s Council on Peripheral Vascular Disease.

Research Interests
  • Cell signaling in/between endothelial cells and smooth muscle cells
  • Vascular anomalies and angiogenesis
  • Lipogenesis and peripheral lipid homeostasis
  • Histone protein post-translational modification and epigenetic regulation
  • Tumor initiation, epithelial-mesenchymal transition and resistance to therapy
Professional Background
  • 07/1995 – 06/1996 Assistant Professor, State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China
  • 07/2006 – 12/2007 Associate Research Scientist, Department of Pharmacology, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, CT
  • 12/2007 – 06/2013 Assistant Professor, Department of Surgery (Primary) and Department of Pathology, Children’s Research Institute, Medical College of Wisconsin, Milwaukee, WI
  • 02/2008 – 06/2013 Assistant Professor (adjunct appointment), Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI
  • 07/2013 – Present Associate Professor, Department of Surgery (Primary) and Department of Pathology, Children’s Research Institute, Medical College of Wisconsin, Milwaukee, WI
  • 07/2013 – Present Associate Professor (adjunct appointment), Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI
Educational Background
  • 09/1986 – 06/1990 BS, Zhejiang University, Hangzhou, China
  • 09/1990 – 06/1995 PhD, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China
  • 09/1997 – 06/2002 PhD, Medical University of South Carolina, Charleston, SC
  • 09/2002 – 07/2006 Postdoctoral Fellow, Department of Pharmacology, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, CT

Publications

Research

Contact Information

Office Address
Children’s Research Institute
9000 W Wisconsin Ave.
Milwaukee, WI 53226