Archive for Research News

Congratulations!

July 23, 2015  |  News, Research News

Mackinnon_Alexander_2013Congratulations! Dr. Alexander C. Mackinnon, Jr., MD, PhD., 3 abstracts for the AMP 2015 Annual Meeting has been accepted for both Poster Presentation and publication in The Journal of Molecular Diagnostics.

 

Poster Number: I05
Category: Informatics
Abstract Title: Research Electronic Data Capture (REDCap) Software for Specimen Tracking and Data Collection Solutions for Translational Research Labs in Academic Medical Institutions

Poster Number: I28
Category: Informatics
Abstract Title: GenomAnalytics: A Software Tool to Identify and Quantify NGS Performance Metrics and Run/Sample-level Thresholds

Poster Number: ST24
Category: Solid Tumors
Abstract Title: Myxoinflammatory Fibroblastic Sarcoma: Association of t(1;10) Translocations in a Cohort of 49 Cases by Fluorescence In Situ Hybridization

USCAP 2012 Conference Paper & Poster Submissions Available

September 21, 2012  |  Department News, Research News

The 101st annual meeting of the USCAP was held in Vancouver, British Columbia, Canada, on March 17 – 23, 2012. Considered the world’s largest gathering of physician pathologists each year, we were able to participate in an historical learning experience. The Department of Pathology participated in paper and poster submissions, as well as Dr. Saul Suster lecturing on Mediastinal Tumors: A Practical Approach with Dr. Cesar Moran of MD Anderson.

The Presence of Residual Normal Peripheral Blood B-Cells in Newly Diagnosed Chronic Lymphocytic Leukemia / Small Lymphocytic Lymphoma (CLL/SLL) Identifies a Good Prognostic Subgroup
Pathologic Response to Neoadjuvant Radiotherapy (NRT) as Potential Prognostic Factor in Soft Tissue Sarcomas (SFS)

Pathologic Response to Neoadjuvant Radiotherapy (NRT) as Potential Prognostic Factor in Soft Tissue Sarcomas (SFS)

Authors: Jason C. Chang, MD1 | David L. Stockman, MD1 | Meena Bedi, MD2 | Dian Wang, MD2 | Eduardo V. Zambrano, MD1

1Department of Pathology and 2Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI

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Most Diffuse Large B-cell Lymphomas are Identified by Flow Cytometry
Morphologic Changes in Myelodysplastic Syndrome Treated With Hypomethylating Agents
Megakaryocytic Hyperplasia Associated with Granulocyte Colony Stimulating Factor

Megakaryocytic Hyperplasia Associated with Granulocyte Colony Stimulating Factor

Authors: Lauren N. Parsons, MD | Horatiu Olteanu, MD, PhD | Steven H. Kroft, MD | Alexandra M. Harrington MD Department... More ›

The Incidence of CD56 Expression by Flow Cytometry in Acute Promyelocytic Leukemia in Patients Treated With All-Trans Retinoic Acid and Anthracycline Drug Combinations

The Incidence of CD56 Expression by Flow Cytometry in Acute Promyelocytic Leukemia in Patients Treated With All-Trans Retinoic Acid and Anthracycline Drug Combinations

Authors: Horatiu Olteanu, MD, PhD | Alexandra M. Harrington MD | Steven H. Kroft, MD Department of Pathology, Medical College of... More ›

Flow Cystometric Blast Immunophenotypes in Acute Myeloid Leukemias Arising from Non-Acute Myeloid Disorders

Flow Cystometric Blast Immunophenotypes in Acute Myeloid Leukemias Arising from Non-Acute Myeloid Disorders

Authors: James Vaughan, MD | Horatiu Olteanu, MD, PhD | Steven H. Kroft, MD | Alexandra M. Harrington MD Department of... More ›

Diagnostic Utility and Comparative Immunohistochemical Analysis of MITF and SOX10 in Melanoma InSitu: A Clinicopathological and Immunohistochemical Study of 50 Cases

Diagnostic Utility and Comparative Immunohistochemical Analysis of MITF and SOX10 in Melanoma InSitu: A Clinicopathological and Immunohistochemical Study of 50 Cases

Authors: J. Noelle Buonaccorsi, MD | Saul Suster, MD | Victor G. Prieto, MD, PhD | Jose A. Plaza, MD Department... More ›

Cutaneous CD30+ Lymphoproliferative Disorder With CD8 Expression. A Clinicopathological Study of 19 Cases

Cutaneous CD30+ Lymphoproliferative Disorder With CD8 Expression. A Clinicopathological Study of 19 Cases

Authors: Jose A. Plaza, MD | Andrew Feldman, MD | Cynthia Magro, MD
Department of Dermatopathology, Weill Cornell Medical Medical College, New York, NY, Mayo Clinic, Rochester, Rochester, MN, and the Medical College of Wisconsin, Milwaukee, WI

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Cribriform Adenocarcinoma of the Lung: Clinicopathologic, Immunohistochemical and Molecular Study of 15 Cases

Cribriform Adenocarcinoma of the Lung: Clinicopathologic, Immunohistochemical and Molecular Study of 15 Cases

Authors: Arturo Luévano, MD | Nagarjun Rao, MD | Alexander Mackinnon, MD, PhD | Saul Suster, MD
Department of Pathology, Clinical and Translational Research Core Lab, Medical College of Wisconsin, Milwaukee, WI

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Comparison of Progranostic Receptors in Primary Breast Cancer and Nodal Metastases
CD200 Expresion in Non-Myeloma Immunoproliferative Disorders
Blast Immunophenotypes by Flow Cytometry in Acute Myeloid Leukemia With Myelodysplasia-Related Changes
Clinicopathologic Findings in Female to Male Gender Reassignment Surgery

Clinicopathologic Findings in Female to Male Gender Reassignment Surgery

Authors:Ellen G. East, M.D., Katherine Gast, M.D.,William Kuzon, M.D., Emily Roberts, B.A., Lili Zhao, PhD., Julie M Jorns, M.D. Michigan Medicine,... More ›

A Core Mission

September 20, 2012  |  Department News, Research News

In order to position faculty and residents so that they are adequately prepared for new advancements in health care, the Department of Pathology at the Medical College of Wisconsin has recently expanded the scope of its educational and scholarly activities. Central to this mission is the establishment of a Clinical and Translational Research Core Lab where residents and faculty in both the pathology department and the medical college have access to histological, immunochemical, and molecular tools to promote their research interests and education.

USCAP-TV went to Wisconsin to see the Core Lab firsthand and learn how the department is having a significant impact on the field.

Connect: Clinical Treatment & Translational Research of Sarcoma at MCW

January 5, 2012  |  Research News

A. Craig Mackinnon, M.D., Ph.D., Eduardo Zambrano, M.D., M.S., Department of Pathology

Sarcomas are tumors involving the connective tissues of the body, such as muscles, bones, fat and other soft tissues. Many different types of sarcomas occur that can be classified and grouped using several classification systems. In addition, sarcomas can demonstrate highly variable clinical behavior and response to conventional surgical, medical, and radiation-based interventions. These factors frequently create challenges for physicians in forming an accurate diagnosis and subsequent treatment strategy. Consequently, most major medical centers employ a multidisciplinary or team-based approach for treating sarcoma patients.

Lipoblast

Microphotograph of a lipoblast, a cell commonly encountered in malignant tumors of fatty tissue (liposarcoma). The cell is surrounded by thin red fibers corresponding to collagen, the main component present in connective tissues.

Despite their large diversity, sarcomas are a relatively rare type of cancer with approximately 10,000 to 15,000 individuals diagnosed with sarcoma annually in the United States. Froedtert & The Medical College of Wisconsin is a nationally recognized center for the treatment of sarcoma. As a result, patients from all over the United States visit us to receive treatment. Sarcoma patients coming to Froedtert & The Medical College haveaccess to some of the most experienced and knowledgeable clinical sarcoma experts in the midwest region of the UnitedStates. Each week, a large group of clinicians representing surgical oncology, orthopaedic surgery, plastic surgery, pathology, medical oncology, radiology, radiation oncology andthoracic oncology — along with clinical staff — meet to discuss and develop optimal treatment plans for these patients.

This has been an exciting year for clinical treatment and translational research of sarcoma at Froedtert & The Medical College. As the title of this article suggests, numerousconnections between departments and faculty have been formedand strengthened during this time. Paralleling the strong multidisciplinary approach we use for diagnosis and treatment of sarcomas, research programs are being established between different investigators and departments. These efforts have been greatly promoted by the genuine interest that is shared amongst our faculty and staff, as well as by recent generous donations being used to fund these projects.

The Sarcoma Connection

As Seen In:The Sarcoma Connection, January, 2012
Download the Full PDF

Sam Pappas, MD, was recently named the Sharon K. Wadina Professor in Sarcoma Research. Using this opportunity, Dr. Pappas has forged research connections with the Department of Pathology (through its Clinical and Translational Research Lab, directed by Craig Mackinnon, MD, PhD) and Human Genetics. The research will use powerful, state-of-the-art molecular techniques to explore and discover novel genetic changes that may drive the formation and growth of sarcoma. These discoveries have the potential to be used clinically for prognostics and therapeutic decisions.

Members of the Department of Pathology led by Eduardo Zambrano, MD, MS, have also recently identified morphologic changes in post-treatment sarcoma tissue samples that strongly and positively correlate with the patient’s response to chemoradiation therapy. By working closely with members of the Department of Radiation Oncology, including Meena Bedi,MD, and Dian Wang, MD, PhD, this collaborative study can hopefully lead to improved treatment strategies and outcomesfor patients being treated at Froedtert & The Medical College.

By combining a shared interest in providing the highest level of care to sarcoma patients with a mutual curiosity to explore themolecular and genetic changes that promote the developmentand growth of sarcoma, physicians and staff at Froedtert & The Medical College are connected, communicating, and committed to further advancing the scope and breadth of treatment options available to patients with sarcoma.